Description

Orexin A (16-33) is a bioactive peptide fragment derived from the neuropeptide Orexin A, which plays a critical role in regulating arousal, wakefulness, and appetite. This specific sequence is essential for research into neuropeptide signaling, receptor binding studies, and the development of diagnostic tools. It is primarily utilized by researchers and developers in the fields of neuroscience, endocrinology, and pharmaceutical development for investigating sleep disorders, metabolic pathways, and potential therapeutic applications.

Application

• Neuroscientific Research: Used as a key reagent in studying the orexinergic system, its role in sleep-wake cycles, narcolepsy, and arousal.
• Receptor Binding & Signal Transduction Assays: Employed in competitive binding studies to characterize interactions with OX1 and OX2 G-protein-coupled receptors.
• Biomarker Development: Serves as a reference standard in the development of immunoassays (ELISA, RIA) for detecting Orexin A levels in biological samples.
• Pharmaceutical R&D: Acts as a precursor or template for the design and screening of novel therapeutic compounds targeting orexin receptors for sleep and eating disorders.
• Academic & Clinical Studies: Facilitates fundamental research in universities and hospitals exploring the link between orexin, energy homeostasis, and addiction.
• Peptide Chemistry & Conjugation: Used in chemical modification studies, including labeling (e.g., with fluorophores or biotin) for imaging and detection applications.

Basic Information

Product Name	Orexin A (16-33)
CAS No.	1374694-00-4
Molecular Formula	C85H134N24O25S2
Molecular Weight	1884.2 g/mol
Synonyms	Hypocretin-1 (16-33); Orexin-A (16-33); hcrt1 (16-33); OXA (16-33); L-Leucine, L-glutamyl-L-tyrosylglycyl-L-leucyl-L-leucyl-L-arginyl-L-glutaminyl-L-leucyl-L-histeryl-L-alanyl-L-alanylglycyl-L-cysteinyl-L-asparaginyl-L-histeryl-L-alanyl-L-cysteinyl-L-seryl-L-threonyl-L-methioninamide, cyclic (4→14)-disulfide; Prepro-orexin (16-33); Preprohypocretin (16-33)
EINECS	Contact for details

Quality Control

Our Orexin A (16-33) is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and MS, are validated to provide reliable data for our global research and pharmaceutical clients.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.