Description

Mal-Peg2-Acid is a heterobifunctional polyethylene glycol (PEG) derivative featuring a maleimide group for thiol conjugation and a carboxylic acid terminus for amine coupling. This compound is essential for creating stable, site-specific bioconjugates and cross-linked biomaterials. It is a critical reagent for researchers and manufacturers in biopharmaceutical development, diagnostic assay production, and advanced drug delivery system engineering.

Application

• Antibody-Drug Conjugate (ADC) Linker: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol groups.
• PEGylation Reagent: Modification of peptides, proteins, and enzymes to enhance solubility, stability, and circulation half-life.
• Hydrogel Formation: Cross-linking agent for creating biocompatible polymer networks for 3D cell culture and tissue engineering scaffolds.
• Surface Functionalization: Immobilization of biomolecules (e.g., proteins, oligonucleotides) onto carboxylated surfaces, chips, or nanoparticles.
• Diagnostic Probe Conjugation: Linking fluorescent dyes, enzymes, or other reporter molecules to targeting ligands like antibodies or aptamers.
• Protein-Protein Cross-linking: For studying protein interactions or creating multimeric protein complexes.

Basic Information

Product Name	Mal-Peg2-Acid
CAS No.	1374666-32-6
Molecular Formula	C15H23NO8
Molecular Weight	345.35 g/mol
Synonyms	Maleimide-PEG2-acid; 3-[2-[2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethoxy]ethoxy]propanoic Acid; Mal-PEG2-COOH; 1-(2-(2-(2-Carboxyethoxy)ethoxy)ethyl)-1H-pyrrole-2,5-dione; Maleimido-PEG2-propionic acid; NHS-PEG2-Maleimide (precursor); mPEG2-Mal; Heterobifunctional PEG linker, Maleimide and Acid
EINECS	Contact for details

Quality Control

Our Mal-Peg2-Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, Acetonitrile, Water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.