Description

Carbamic Acid, n-[[1-[(5-Bromo-2-Chloro-4-Pyrimidinyl)Amino]Cyclohexyl]Methyl]-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate designed for the synthesis of complex active pharmaceutical ingredients (APIs). This compound is critical for research and development in medicinal chemistry, offering a key building block for novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on oncology, antiviral, and other specialized drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the multi-step synthesis of targeted small molecule drugs.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies for new drug candidates.
• API Synthesis: A key building block in the production route of complex final active pharmaceutical ingredients.
• Oncology Drug Development: Particularly relevant for creating compounds targeting specific enzymatic pathways.
• Biochemical Research: Employed in the development of chemical probes and inhibitors for biological studies.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for cGMP production.

Basic Information

Product Name	Carbamic Acid, n-[[1-[(5-Bromo-2-Chloro-4-Pyrimidinyl)Amino]Cyclohexyl]Methyl]-, 1,1-Dimethylethyl Ester
CAS No.	1374635-87-6
Molecular Formula	C17H24BrClN4O2
Molecular Weight	431.75 g/mol
Synonyms	tert-Butyl N-[[1-[(5-bromo-2-chloropyrimidin-4-yl)amino]cyclohexyl]methyl]carbamate; 1,1-Dimethylethyl N-[[1-[(5-bromo-2-chloro-4-pyrimidinyl)amino]cyclohexyl]methyl]carbamate; (5-Bromo-2-chloro-pyrimidin-4-yl)-cyclohexylmethyl-carbamic acid tert-butyl ester; BOC-protected amino pyrimidine intermediate; CAS 1374635-87-6
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical pharmaceutical applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We operate under a quality management system and can supply material suitable for use under cGMP (current Good Manufacturing Practice) guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.