Description

5-Methyl-2-(Pyrimidin-2-Yl)Benzonitrile is a high-purity, advanced pharmaceutical intermediate featuring a benzonitrile core substituted with a pyrimidine ring. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily sought by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, including kinase inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of targeted drug candidates, especially in oncology and antiviral research.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Serves as a core structural component in the design and synthesis of novel protein kinase inhibitors.
• Chemical Synthesis: Employed in organic synthesis for constructing complex heterocyclic systems due to its reactive nitrile and aromatic pyrimidine groups.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection products.
• Material Science: Investigated as a monomer or building block for specialty polymers and functional organic materials.

Basic Information

Product Name	5-Methyl-2-(Pyrimidin-2-Yl)Benzonitrile
CAS No.	1373917-20-4
Molecular Formula	C12H9N3
Molecular Weight	195.22 g/mol
Synonyms	2-(5-Methyl-2-cyanophenyl)pyrimidine; 2-(2-Cyano-4-methylphenyl)pyrimidine; 5-Methyl-2-(2-pyrimidinyl)benzonitrile; 2-Pyrimidinyl-5-methylbenzonitrile; 2-(Pyrimidin-2-yl)-5-methylbenzonitrile; Benzonitrile, 5-methyl-2-(2-pyrimidinyl)-; 1373917-20-4
EINECS	Contact for details

Quality Control

Our production of 5-Methyl-2-(Pyrimidin-2-Yl)Benzonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your R&D and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this moisture-sensitive material from humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.