Description

C-(5-Fluoro-Pyrimidin-2-Yl)-Methylamine Dihydrochloride is a high-purity, fluorinated pyrimidine derivative dihydrochloride salt, serving as a critical pharmaceutical intermediate and building block in advanced organic synthesis. Its value lies in providing a functionalized scaffold essential for constructing complex molecules in drug discovery and development programs. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially kinase inhibitors and antiviral agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its fluorinated pyrimidine core.
• Chemical Biology Probes: Serves as a precursor for developing labeled compounds and molecular probes for target identification and validation.
• Agrochemical Synthesis: Intermediate in the development of advanced pesticides and herbicides that utilize pyrimidine chemistry.
• Academic Research: Utilized in universities and research institutes for studying heterocyclic chemistry and fluorine substitution effects.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific synthesis projects.

Basic Information

Product Name	C-(5-Fluoro-Pyrimidin-2-Yl)-Methylamine Dihydrochloride
CAS No.	1373223-30-3
Molecular Formula	C5H7F N3 • 2HCl
Molecular Weight	215.06 g/mol (Free base: 143.13 g/mol)
Synonyms	(5-Fluoropyrimidin-2-yl)methanamine dihydrochloride; 2-(Aminomethyl)-5-fluoropyrimidine dihydrochloride; 5-Fluoro-2-pyrimidinemethanamine dihydrochloride; 1-(5-Fluoropyrimidin-2-yl)methanamine dihydrochloride; (5-Fluoro-2-pyrimidinyl)methylamine dihydrochloride; C-(5-Fluoro-2-pyrimidyl)-methylamine dihydrochloride; 5-Fluoro-2-(aminomethyl)pyrimidine dihydrochloride
EINECS	Contact for details

Quality Control

Our C-(5-Fluoro-Pyrimidin-2-Yl)-Methylamine Dihydrochloride is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring GMP-grade intermediates and materials for regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.