Description

1-[2-(Trifluoromethyl)Pyrimidin-5-Yl]Ethanone is a high-purity fluorinated pyrimidine derivative, serving as a critical advanced pharmaceutical intermediate and building block for complex organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl-pyrimidine scaffold, which is essential for modulating the biological activity, metabolic stability, and lipophilicity of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and production of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used as a building block for developing new generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Material Science Research: Employed in the synthesis of specialty chemicals, ligands, and fluorinated polymers for advanced material applications.
• Chemical Biology Probes: Serves as a precursor for creating labeled compounds and molecular probes used in biochemical assay development and diagnostic research.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up services under cGMP or ISO standards.

Basic Information

Product Name	1-[2-(Trifluoromethyl)Pyrimidin-5-Yl]Ethanone
CAS No.	1367970-52-2
Molecular Formula	C7H5F3N2O
Molecular Weight	190.12 g/mol
Synonyms	5-Acetyl-2-(trifluoromethyl)pyrimidine; 2-(Trifluoromethyl)pyrimidin-5-yl methyl ketone; Ethanone, 1-[2-(trifluoromethyl)-5-pyrimidinyl]-; 1-(2-(Trifluoromethyl)pyrimidin-5-yl)ethan-1-one; 5-Acetyl-2-trifluoromethylpyrimidine; 2-Trifluoromethyl-5-acetylpyrimidine; CAS 1367970-52-2
EINECS	Contact for details

Quality Control

Our 1-[2-(Trifluoromethyl)Pyrimidin-5-Yl]Ethanone is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment supports applications requiring research-grade to cGMP-grade materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.