Description

3-Iodo-4-(Trifluoromethoxy)Aniline is a high-purity, multi-functional aromatic amine building block characterized by its unique halogenated and fluorinated substituents. This compound is critical for advanced organic synthesis, enabling the introduction of both iodine and trifluoromethoxy groups into complex molecular architectures. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients, as well as by material scientists developing specialty polymers and liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-infective agents.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethoxy group.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of advanced polymers, dyes, and liquid crystalline materials with specific electronic or optical properties.
• Chemical Research & Development: An essential building block for method development in cross-coupling reactions (e.g., Suzuki, Sonogashira) and for creating compound libraries in high-throughput screening.
• Fluorine Chemistry: A valuable substrate for studying the influence of the -OCF3 moiety on molecular conformation, lipophilicity, and metabolic stability.

Basic Information

Item	Details
Product Name	3-Iodo-4-(Trifluoromethoxy)Aniline
CAS No.	1365969-58-9
Molecular Formula	C7H5F3INO
Molecular Weight	302.99 g/mol
Synonyms	4-Amino-2-iodo-1-(trifluoromethoxy)benzene; 2-Iodo-4-(trifluoromethoxy)benzenamine; 3-Iodo-4-(trifluoromethoxy)phenylamine; 4-(Trifluoromethoxy)-3-iodoaniline; 3-Iodo-4-trifluoromethoxyaniline; 2-Iodo-α,α,α-trifluoro-p-anisidine; Benzenamine, 3-iodo-4-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 3-Iodo-4-(Trifluoromethoxy)Aniline is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and KF titration for moisture content. We provide a Certificate of Analysis (COA) with every shipment, detailing all specifications and test results to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and easily oxidized nature, it is recommended to handle the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to minimize exposure to air and moisture during use.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.