Description

2-Chloro-4-Fluoro-5-Methylbenzylamine is a versatile halogenated benzylamine building block of significant importance in advanced organic synthesis. This compound matters because its unique substitution pattern provides a reactive amine handle and a halogenated aromatic core, enabling the construction of complex molecular architectures. It is primarily needed by pharmaceutical, agrochemical, and specialty chemical R&D teams for applications in medicinal chemistry and as a precursor for functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system and metabolic disorders.
• Agrochemical Synthesis: Used in the preparation of novel herbicides, fungicides, and insecticides, leveraging the fluorine and chlorine atoms for bioactivity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis.
• Functional Material Precursor: Employed in the synthesis of advanced polymers, liquid crystals, or organic electronic materials.
• Chemical Biology Probes: Utilized to create tagged molecules or affinity probes for studying biological pathways and target engagement.
• Custom Synthesis Building Block: Provides a versatile starting point for contract research organizations (CROs) and fine chemical manufacturers for client-specific molecule assembly.

Basic Information

Product Name	2-Chloro-4-Fluoro-5-Methylbenzylamine
CAS No.	1365968-65-5
Molecular Formula	C8H9ClFN
Molecular Weight	173.61 g/mol
Synonyms	1-(Aminomethyl)-2-chloro-4-fluoro-5-methylbenzene; (2-Chloro-4-fluoro-5-methylphenyl)methanamine; 5-(Aminomethyl)-2-chloro-4-fluorotoluene; 2-Chloro-4-fluoro-5-methylbenzenemethanamine; 2-Chloro-4-fluoro-5-methyl-benzylamine; α-Amino-2-chloro-4-fluoro-5-methyltoluene; Benzenemethanamine, 2-chloro-4-fluoro-5-methyl-
EINECS	Contact for details

Quality Control

Our 2-Chloro-4-Fluoro-5-Methylbenzylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material produced under current Good Manufacturing Practice (cGMP) guidelines as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.