Description

2,2-Difluoro-2-(2-Methylphenyl)Ethan-1-Amine is a specialized fluorinated amine building block of significant interest in advanced organic synthesis. Its unique structure, featuring a difluoromethyl group adjacent to an amine on a substituted phenyl ring, makes it a valuable precursor for creating novel molecular architectures. This compound is primarily sought by research and development chemists in the pharmaceutical and agrochemical industries. It serves as a critical intermediate for the development of new active ingredients, where the introduction of fluorine atoms can dramatically alter biological activity, metabolic stability, and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, where fluorination is a common strategy to enhance efficacy and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts used in asymmetric synthesis, leveraging the amine functionality for metal coordination or activation.
• Material Science Precursor: Potential monomer or functionalization agent in the synthesis of specialty polymers, resins, or advanced materials with tailored surface properties.
• Fluorine Chemistry Research: A valuable substrate for studying the reactivity of gem-difluorinated compounds and for developing new fluorination methodologies.

Basic Information

Product Name	2,2-Difluoro-2-(2-Methylphenyl)Ethan-1-Amine
CAS No.	1365807-92-6
Molecular Formula	C9H11F2N
Molecular Weight	171.19 g/mol
Synonyms	1-(2-Methylphenyl)-2,2-difluoroethanamine; 2,2-Difluoro-2-(o-tolyl)ethanamine; α,α-Difluoro-o-tolylmethylamine; 2-Methyl-α,α-difluorobenzeneethanamine; 2-(2-Methylphenyl)-2,2-difluoroethanamine; o-Tolyl-α,α-difluoromethylamine; 2,2-Difluoro-1-(2-methylphenyl)ethanamine
EINECS	Contact for details

Quality Control

Every batch of 2,2-Difluoro-2-(2-Methylphenyl)Ethan-1-Amine is produced and analyzed under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing, including chromatographic purity assays and identity confirmation, to meet the exacting standards required for synthetic chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.