Description

Biotin-Peg2-Acid CAS NO 1365655-89-5 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring a biotin group for affinity binding and a terminal carboxylic acid for covalent conjugation. This compound is essential for creating stable, site-specific bioconjugates used in advanced diagnostics, targeted drug delivery, and proteomics research. It is primarily utilized by pharmaceutical R&D teams, diagnostic kit manufacturers, and academic research institutions focused on developing next-generation biotherapeutics and analytical tools.

Application

• ADC (Antibody-Drug Conjugate) Development: Serves as a key linker component to attach cytotoxic payloads to monoclonal antibodies, enabling targeted cancer therapies.
• Diagnostic Assay Reagents: Used to biotinylate proteins, antibodies, or nucleic acids for capture and detection in ELISA, lateral flow assays, and other immunoassay platforms.
• Affinity Chromatography: Functionalizes solid supports (e.g., agarose beads) to create streptavidin/biotin-based purification columns for isolating specific biomolecules.
• Surface Functionalization: Enables the immobilization of biomolecules onto sensor chips, nanoparticles, or other materials for biosensing and biomedical device applications.
• Proteomics & Protein Labeling: Facilitates the tagging and subsequent isolation of proteins for interaction studies, pull-down assays, and mass spectrometry analysis.
• Drug Delivery Systems: Incorporated into liposomes, polymers, or other nanocarriers to create targeted delivery vehicles with enhanced pharmacokinetic properties.

Basic Information

Item	Detail
Product Name	Biotin-Peg2-Acid
CAS No.	1365655-89-5
Molecular Formula	C19H32N4O7S
Molecular Weight	460.55 g/mol
Synonyms	Biotin-PEG2-acid; Biotin-PEG2-COOH; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-carboxyethoxy)ethoxy)ethyl)pentanamide; Biotin-amido-PEG2-propionic acid; Biotin-PEG2-Propionic Acid; Biotin-PEG2-CH2CH2COOH; Biotin-PEG2-C2-acid; Biotinyl-PEG2-acid
EINECS	Contact for details

Quality Control

Our Biotin-Peg2-Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for moisture and residual solvents. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.