Description

Methyl 4-Chloro-7-Phenylsulfonyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylate is a high-value, multi-functional heterocyclic building block essential for modern pharmaceutical research and development. This compound serves as a critical synthetic intermediate in the creation of novel, targeted therapeutic agents, particularly kinase inhibitors. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule kinase inhibitors for oncology and inflammatory disease research.
• Chemical Biology Probe Development: Used to create tool compounds for studying specific enzyme pathways and target validation.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• API Synthesis: Employed in the multi-step synthesis of complex drug candidates under cGMP conditions for preclinical and clinical trials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting global drug discovery pipelines.
• Academic Research: Used in university and institutional labs for fundamental research in heterocyclic chemistry and drug design.

Basic Information

Item	Details
Product Name	Methyl 4-Chloro-7-Phenylsulfonyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylate
CAS No.	1363382-96-0
Molecular Formula	C14H10ClN3O4S
Molecular Weight	351.76 g/mol
Synonyms	Methyl 4-chloro-7-(phenylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate; 4-Chloro-7-phenylsulfonyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylic acid methyl ester; 1363382-96-0; Pyrrolo[2,3-d]pyrimidine-6-carboxylate, methyl 4-chloro-7-(phenylsulfonyl)-7H-; Methyl 4-chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine-6-carboxylate (common name variant)
EINECS	Contact for details

Quality Control

Our Methyl 4-Chloro-7-Phenylsulfonyl-7H-Pyrrolo[2,3-D]Pyrimidine-6-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Products undergo rigorous analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The container should be kept in a well-ventilated area and protected from moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.