Description

2-Piperidin-4-Ylmethyl-4-Trifluoromethyl-Pyrimidine is a specialized heterocyclic organic compound featuring a pyrimidine core substituted with a trifluoromethyl group and a piperidinylmethyl moiety. This molecular architecture makes it a valuable advanced pharmaceutical intermediate and a key building block in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block in the research and synthesis of new drug candidates, particularly in areas targeting central nervous system (CNS) disorders and other therapeutic areas.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel active ingredients for crop protection products, leveraging the stability imparted by the trifluoromethyl group.
• Chemical Biology Probe Development: Employed in the creation of molecular probes to study biological pathways and protein functions.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects requiring complex, fluorinated heterocycles.

Basic Information

Product Name	2-Piperidin-4-Ylmethyl-4-Trifluoromethyl-Pyrimidine
CAS No.	1359702-39-8
Molecular Formula	C11H14F3N3
Molecular Weight	245.25 g/mol
Synonyms	4-((4-(Trifluoromethyl)pyrimidin-2-yl)methyl)piperidine; 2-((Piperidin-4-yl)methyl)-4-(trifluoromethyl)pyrimidine; 4-(Trifluoromethyl)-2-(4-piperidinylmethyl)pyrimidine; 2-(Piperidin-4-ylmethyl)-4-trifluoromethylpyrimidine; 4-(Trifluoromethyl)-2-piperidin-4-ylmethylpyrimidine; 1359702-39-8; 2-(4-Piperidylmethyl)-4-trifluoromethyl-pyrimidine
EINECS	Contact for details

Quality Control

Our 2-Piperidin-4-Ylmethyl-4-Trifluoromethyl-Pyrimidine is produced under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent identity. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support cGMP standards for advanced intermediate production where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.