Description

4-Chloro-2-Ethyl-5-Fluoro-Pyrimidine is a high-purity halogenated pyrimidine building block essential for advanced organic synthesis. This compound matters as a critical intermediate for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, especially in antiviral and anticancer research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides.
• Chemical Research: Serves as a versatile scaffold for medicinal chemistry and structure-activity relationship (SAR) studies.
• Material Science: Potential precursor for the synthesis of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: The chloro and fluoro substituents make it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions.
• Nucleoside Analogue Development: Used in the synthesis of modified nucleosides and nucleotides for biochemical applications.

Basic Information

Product Name	4-Chloro-2-Ethyl-5-Fluoro-Pyrimidine
CAS No.	1359701-88-4
Molecular Formula	C6H6ClFN2
Molecular Weight	160.58 g/mol
Synonyms	4-Chloro-2-ethyl-5-fluoropyrimidine; 2-Ethyl-4-chloro-5-fluoropyrimidine; 5-Fluoro-2-ethyl-4-chloropyrimidine; Pyrimidine, 4-chloro-2-ethyl-5-fluoro-; 1359701-88-4; 4-Chloro-2-ethyl-5-fluoro-1,3-diazine
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-Ethyl-5-Fluoro-Pyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for all shipments. We adhere to cGMP standards where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.