Description

Ethyl-S-(+)-Clopidogrel Sulfate is the ethyl ester salt of the active metabolite of the widely used antiplatelet agent, Clopidogrel. This high-purity intermediate is critical for pharmaceutical research and development, offering a direct route to study the biological activity and metabolism of the parent drug. It is primarily utilized by pharmaceutical manufacturers and research institutions engaged in the development of cardiovascular therapeutics, analytical method development, and impurity profiling.

Application

• Pharmaceutical Intermediate: Key starting material (KSM) or advanced intermediate in the synthesis of Clopidogrel and its novel derivatives.
• Reference Standard: Serves as a certified reference material (CRM) for quality control, HPLC/LC-MS method development, and validation in API manufacturing.
• Metabolite Studies: Used in pharmacological and pharmacokinetic research to investigate the in vivo activation pathway and efficacy of Clopidogrel.
• Impurity Standard: Essential for identifying, quantifying, and controlling process-related impurities and degradation products in final drug substance batches.
• Analytical Research: Employed in academic and industrial laboratories for bioanalytical assays and comparative stability studies.

Basic Information

Product Name	Ethyl-S-(+)-Clopidogrel Sulfate
CAS No.	1357474-92-0
Molecular Formula	C18H20ClNO6S
Molecular Weight	413.87 g/mol
Synonyms	(+)-Clopidogrel Ethyl Ester Sulfate; S-(+)-Clopidogrel Ethyl Ester Hydrogen Sulfate; Ethyl (S)-Clopidogrel Sulfate; Methyl 2-(2-Chlorophenyl)-2-((6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate Ethyl Ester Sulfate; Clopidogrel Active Metabolite Ethyl Ester Salt; SR 26334 Ethyl Ester; CAS 1357474-92-0
EINECS	Contact for details

Quality Control

Our Ethyl-S-(+)-Clopidogrel Sulfate is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by IR and NMR spectroscopy, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert conditions (e.g., nitrogen atmosphere) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Chiral Purity (HPLC)	≥ 99.0% (S-Isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.