Description

1-(1-Methylethyl)-3-(2-Phenylethynyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine is a high-purity, advanced pharmaceutical intermediate and research chemical. This compound is a key building block in the synthesis of targeted therapeutic agents, particularly in oncology and kinase inhibitor research. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in developing novel drug candidates.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of potent kinase inhibitors for targeted cancer therapies.
• Biochemical Research: Used as a reference standard and active probe in enzymatic assays and structure-activity relationship (SAR) studies.
• Drug Discovery & Development: Serves as a core scaffold for medicinal chemists to develop new chemical entities (NCEs) with optimized pharmacological profiles.
• Academic Research: Employed in university and institutional labs for investigating signal transduction pathways and cellular mechanisms.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Preclinical Development: Utilized in the preparation of compounds for in vitro and in vivo efficacy and toxicity testing.

Basic Information

Product Name	1-(1-Methylethyl)-3-(2-Phenylethynyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine
CAS No.	1357349-91-7
Molecular Formula	C₁₈H₁₇N₅
Molecular Weight	303.36 g/mol
Synonyms	1-Isopropyl-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 3-(2-Phenylethynyl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-; Kinase Inhibitor Intermediate; Pyrazolopyrimidine Derivative; CAS 1357349-91-7
EINECS	Contact for details

Quality Control

Our production of 1-(1-Methylethyl)-3-(2-Phenylethynyl)-1H-Pyrazolo[3,4-D]Pyrimidin-4-Amine adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.