Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4,4-Dimethylpentanoic Acid is a specialized, high-purity amino acid derivative designed for advanced synthetic chemistry. This compound is a critical building block for the synthesis of complex peptides and modified biomolecules, offering precise stereochemical control. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and advanced materials science who require reliable, high-quality intermediates for their most demanding projects.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected, methylated amino acid derivative, it is a key intermediate for introducing sterically hindered, non-proteinogenic amino acids into peptide chains.
• Pharmaceutical Research & Development: Used in the discovery and synthesis of novel peptide-based therapeutics, including enzyme inhibitors and receptor modulators.
• Peptidomimetic Design: The 4,4-dimethylpentanoic acid side chain provides a unique hydrophobic and bulky structural motif for creating stable peptide mimics with enhanced metabolic stability.
• Bioconjugation and Linker Chemistry: Serves as a specialized component for constructing custom linkers in antibody-drug conjugates (ADCs) and other bioconjugation strategies.
• Chemical Biology Probes: Utilized to synthesize labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• Process Development for API Manufacturing: Acts as a critical raw material in the scalable production of active pharmaceutical ingredients (APIs) containing modified amino acid sequences.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4,4-Dimethylpentanoic Acid
CAS No.	1357308-53-2
Molecular Formula	C24H27NO5
Molecular Weight	409.48 g/mol
Synonyms	Fmoc-N-Me-Dmp-OH; Fmoc-N-methyl-2-amino-4,4-dimethylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-leucine; N-Fmoc-N-methyl-D-leucine; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl](methyl)amino]-4,4-dimethylpentanoic acid; Fmoc-N-Me-D-Leu-OH; Nα-Fmoc-Nα-methyl-D-leucine; D-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-4,4-dimethylpentanoic acid
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}(Methyl)Amino)-4,4-Dimethylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical research and development. Certificates of Analysis (COA) documenting identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥97.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.