Description

n-Fmoc-L-Threonine (2-Tolyl-2-Oxo-Ethyl)Ester is a specialized, protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity building blocks to construct complex peptide sequences with precise stereochemistry. It is primarily utilized by the pharmaceutical, biotechnology, and life sciences industries for applications in drug discovery, proteomics, and the development of therapeutic peptides.

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key Fmoc-protected threonine derivative for the automated synthesis of peptides, ensuring side-chain protection during chain elongation.
• Pharmaceutical Intermediate: Used in the research and development of novel peptide-based therapeutics, including hormone analogs and enzyme inhibitors.
• Bioconjugation: Acts as a precursor for creating peptide-protein or peptide-small molecule conjugates for targeted drug delivery systems.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to identify new bioactive compounds.
• Academic & Industrial Research: Essential for fundamental studies in peptide structure-activity relationships (SAR) and chemical biology.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific, high-value peptide sequences for clients.

Basic Information

Product Name	n-Fmoc-L-Threonine (2-Tolyl-2-Oxo-Ethyl)Ester
CAS No.	1356841-91-2
Molecular Formula	C27H25NO6
Molecular Weight	459.49 g/mol
Synonyms	Fmoc-Thr(2-Tolyl-2-oxo-ethyl)-OH; Fmoc-L-Threonine(2-Tolyl-2-Oxo-Ethyl) Ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-threonine 2-(2-methylphenyl)-2-oxoethyl ester; (2S,3R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-3-hydroxybutanoic acid 2-(2-methylphenyl)-2-oxoethyl ester; Fmoc-Thr(2-Tolyl-OE)-OH; Protected L-Threonine derivative; Fmoc-Threonine(O-(2-Methylbenzoyl)methyl) ester
EINECS	Contact for details

Quality Control

Our n-Fmoc-L-Threonine (2-Tolyl-2-Oxo-Ethyl)Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification (NMR, MS), to ensure it meets the high standards required for sensitive peptide synthesis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.