Description

3-Bromo-4-Fluoro-5-Nitroaniline is a high-purity halogenated aniline derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromo, fluoro, and nitro substituents on an aniline core, makes it an indispensable intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and pesticides, where the halogen and nitro groups contribute to biological activity and metabolic stability.
• Dye and Pigment Manufacturing: Serves as a starting material for the production of complex azo dyes and high-performance pigments, imparting color fastness and specific light-absorption properties.
• Material Science Research: Employed in the creation of organic semiconductors, liquid crystals, and polymers where precise molecular architecture is required for electronic or optical performance.
• Cross-Coupling Reactions: The bromo substituent makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to form biaryl structures.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes and tags for studying biological processes and diagnostic applications.

Basic Information

Product Name	3-Bromo-4-Fluoro-5-Nitroaniline
CAS No.	1356493-54-3
Molecular Formula	C6H4BrFN2O2
Molecular Weight	235.01 g/mol
Synonyms	5-Amino-2-bromo-1-fluoro-4-nitrobenzene; 2-Bromo-1-fluoro-4-nitro-5-aminobenzene; 3-Bromo-4-fluoro-5-nitrobenzenamine; Benzenamine, 3-bromo-4-fluoro-5-nitro-; 3-Br-4-F-5-NO2-Aniline
EINECS	Contact for details

Quality Control

Our 3-Bromo-4-Fluoro-5-Nitroaniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We employ advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry for verification. Certificates of Analysis (COA) are available upon request and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect purity and stability. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.