Description

5-Amino-2,3-Difluorophenol is a fluorinated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of pharmaceuticals, agrochemicals, and functional materials, where its unique difluoro-amino-phenol structure enables precise molecular modifications. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to introduce specific fluorine and hydroxyl functionalities into target molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and pesticides, where fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorine-containing compounds used in electronic displays and organic light-emitting diodes (OLEDs).
• Polymer Modification: Employed to introduce fluorinated phenolic groups into polymer chains, altering thermal stability, solubility, and surface properties.
• Dye & Pigment Intermediate: Utilized in the synthesis of specialized fluorinated dyes and pigments for high-performance applications.
• Cross-Coupling Reactions: Acts as a substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to construct complex biaryl structures.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for screening.

Basic Information

Product Name	5-Amino-2,3-Difluorophenol
CAS No.	1356339-34-8
Molecular Formula	C6H5F2NO
Molecular Weight	145.11 g/mol
Synonyms	2,3-Difluoro-5-aminophenol; 5-Amino-2,3-difluorophenol; 2,3-Difluoro-5-hydroxyaniline; 3-Amino-4,5-difluorophenol; 5-Amino-2,3-difluoro-1-hydroxybenzene; 1-Hydroxy-3-amino-4,5-difluorobenzene; Phenol, 5-amino-2,3-difluoro-
EINECS	Contact for details

Quality Control

Our 5-Amino-2,3-Difluorophenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR, to ensure compliance with stringent industry standards. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). This compound is light-sensitive and may be hygroscopic; keep the container tightly sealed under an inert atmosphere for long-term storage to prevent oxidation and moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.