Description

Fmoc-n-Methyl-D-Allo-Isoleucine is a protected, non-proteinogenic amino acid derivative designed for advanced peptide synthesis. This high-purity building block is critical for introducing the unique steric and conformational properties of the N-methylated D-allo-isoleucine residue into peptide chains. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, peptidomimetics, and bioactive compounds where backbone modification and chiral control are essential.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the Fmoc-strategy synthesis of complex peptides, enabling the incorporation of a constrained, N-alkylated D-amino acid.
• Peptidomimetic Drug Discovery: Used to create peptide analogs with enhanced metabolic stability, membrane permeability, and receptor selectivity by introducing N-methylation and non-natural chirality.
• Bioactive Peptide Research: Essential for constructing peptides with specific secondary structures or for probing structure-activity relationships (SAR) in hormone, antibiotic, or neurotransmitter analogs.
• Combinatorial Chemistry Libraries: Serves as a valuable building block for generating diverse chemical libraries focused on peptide-based targets.
• Conformational Studies: Employed in academic and industrial research to study the impact of N-methylation and D-allo configuration on peptide folding and stability.

Basic Information

Product Name	Fmoc-n-Methyl-D-Allo-Isoleucine
CAS No.	1356090-81-7
Molecular Formula	C22H25NO5
Molecular Weight	383.44 g/mol
Synonyms	Fmoc-N-Me-D-allo-Ile-OH; (2R,3S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)(methyl)amino)-3-methylpentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-D-allo-isoleucine; Fmoc-N-methyl-D-alloisoleucine; N-Fmoc-N-methyl-D-allo-isoleucine
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-D-Allo-Isoleucine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral integrity, and impurity profiles. We adhere to relevant industry standards for fine chemicals used in pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.