Description

1,8-Bis(Cystineyl)-3,6-Dioxa-Octane Dihydrochloride is a specialized, high-purity biochemical building block featuring a polyethylene glycol (PEG) spacer linking two cystine moieties. This compound is critical for advanced research and development in peptide chemistry and bioconjugation, offering a controlled method to introduce disulfide bridges and enhance solubility. It is primarily utilized by pharmaceutical R&D teams, biotech companies, and academic researchers focused on drug delivery systems, protein engineering, and the synthesis of complex biomolecules.

Application

• Peptide & Protein Conjugation: Acts as a versatile linker for creating dimeric peptide constructs or attaching payloads via disulfide bond formation.
• Drug Delivery System Development: Used in the design of targeted therapeutics and prodrugs where a cleavable, PEGylated linker is required.
• Biomaterial Functionalization: Serves as a cross-linking agent or surface modifier to introduce thiol-reactive groups onto polymers or nanoparticles.
• Antibody-Drug Conjugate (ADC) Research: A valuable intermediate for exploring novel linker technologies in ADC platforms.
• Chemical Biology Probes: Enables the synthesis of tools for studying redox biology and protein-protein interactions.
• Stapled Peptide Synthesis: Can be employed to create macrocyclic peptides with enhanced stability and biological activity.

Basic Information

Product Name	1,8-Bis(Cystineyl)-3,6-Dioxa-Octane Dihydrochloride
CAS No.	1356019-49-2
Molecular Formula	C20H38Cl2N4O10S2
Molecular Weight	637.6 g/mol
Synonyms	1,8-Bis(cystineyl)-3,6-dioxaoctane dihydrochloride; Cystine-PEG2-Cystine dihydrochloride; Bis(L-cystine) PEG2 derivative dihydrochloride; 3,6-Dioxaoctane-1,8-diyl bis(2-amino-3-[(carboxymethyl)carbamoyl]-3-sulfanylpropanoate) dihydrochloride; (S,S)-1,1'-(3,6-Dioxaoctane-1,8-diyl) bis(2-amino-3-((carboxymethyl)carbamoyl)-3-sulfanylpropanoic acid) dihydrochloride
EINECS	Contact for details

Quality Control

Our 1,8-Bis(Cystineyl)-3,6-Dioxa-Octane Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity verification, and identity confirmation to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.