Description

2-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidin-6-Amine is a high-purity, advanced pharmaceutical intermediate characterized by its unique pyrazolopyrimidine core and trifluoromethyl substituent. This compound is essential for medicinal chemistry research and development, offering a critical building block for the synthesis of novel bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of new therapeutic agents, particularly in oncology and kinase inhibitor programs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Kinase Inhibitor Research: Serves as a core scaffold for designing and synthesizing potent and selective kinase inhibitors due to the pyrazolopyrimidine structure's affinity for ATP-binding sites.
• Medicinal Chemistry & Drug Discovery: Used in lead optimization and structure-activity relationship (SAR) studies to improve pharmacokinetic properties and efficacy of candidate drugs.
• Oncology Therapeutics: Employed in the synthesis of investigational new drugs for cancer treatment, leveraging its potential to modulate critical cellular signaling pathways.
• Chemical Biology Probes: Utilized to create tool compounds for studying enzyme function and biological mechanisms in vitro and in vivo.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up synthesis under cGMP conditions for clinical trial material production.

Basic Information

Product Name	2-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidin-6-Amine
CAS No.	1356003-25-2
Molecular Formula	C7H5F3N4
Molecular Weight	202.14 g/mol
Synonyms	6-Amino-2-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine; 2-(Trifluoromethyl)-6-aminopyrazolo[1,5-a]pyrimidine; Pyrazolo[1,5-a]pyrimidin-6-amine, 2-(trifluoromethyl)-; 1356003-25-2; 2-Trifluoromethylpyrazolo[1,5-a]pyrimidin-6-ylamine; 6-Amino-2-trifluoromethylpyrazolo[1,5-a]pyrimidine
EINECS	Contact for details

Quality Control

Every batch of 2-(Trifluoromethyl)Pyrazolo[1,5-A]Pyrimidin-6-Amine is manufactured under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are suitable for research and development use, with specifications tailored to meet the stringent requirements of pharmaceutical applications. Certificates of Analysis (COA) documenting purity (typically by HPLC), identity (by IR, NMR), and impurity profiles are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.