Description

4-(4-Amino-Phenyl)-Pyrimidine-2-Thiol is a high-purity organic building block featuring a pyrimidine core functionalized with an amino-phenyl group and a thiol moiety. This compound matters as a versatile and critical intermediate for synthesizing advanced pharmaceutical compounds and functional materials. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and ligands.

Application

• Pharmaceutical Intermediate: A key synthon for the development of kinase inhibitors, anticancer agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators.
• Material Science: Serves as a precursor for metal-organic frameworks (MOFs), coordination polymers, and functional dyes.
• Chemical Biology: Employed in the design of enzyme inhibitors, probes, and bioconjugation reagents due to its reactive thiol and amino groups.
• Catalyst Ligand Synthesis: Utilized to create novel ligands for transition metal catalysis in asymmetric synthesis.
• Academic & Industrial R&D: A valuable compound for exploratory chemistry and process development in both university and corporate laboratories.

Basic Information

Product Name	4-(4-Amino-Phenyl)-Pyrimidine-2-Thiol
CAS No.	1355334-87-0
Molecular Formula	C10H9N3S
Molecular Weight	203.26 g/mol
Synonyms	2-Mercapto-4-(4-aminophenyl)pyrimidine; 4-(4-Aminophenyl)-2-pyrimidinethiol; 4-(4-Aminophenyl)pyrimidine-2-thiol; 2-Pyrimidinethiol, 4-(4-aminophenyl)-; 4-(p-Aminophenyl)-2-pyrimidinethiol; 4-(4-Aminophenyl)-2-mercaptopyrimidine; 2-Mercapto-4-(p-aminophenyl)pyrimidine
EINECS	Contact for details

Quality Control

Our 4-(4-Amino-Phenyl)-Pyrimidine-2-Thiol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all specifications and test results. Our quality commitment supports applications requiring high-purity intermediates for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C under an inert atmosphere (e.g., nitrogen or argon) due to its sensitivity to oxidation. Keep away from strong oxidizing agents. For long-term storage, consider refrigeration at 2-8°C.

Specification

Item	Specification
Appearance	Yellow to light brown powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.