Description

D-Ribofuranose, 1-C-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-Yl)-2,3,5-Tris-o-(Phenylmethyl)- is a sophisticated, protected nucleoside analog intermediate of significant interest in advanced pharmaceutical research and development. This compound is specifically engineered to serve as a key building block in the synthesis of novel therapeutic agents, particularly antiviral and anticancer nucleoside analogs. It is essential for medicinal chemists and process development scientists working in pharmaceutical R&D, contract manufacturing organizations (CMOs), and fine chemical synthesis who require high-purity, structurally complex intermediates to accelerate their drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel nucleoside-based antiviral and anticancer drug candidates.
• Antiviral Drug Development: Used in research targeting the synthesis of modified nucleosides for potential activity against viruses such as hepatitis, influenza, and other RNA viruses.
• Oncology Research: Serves as a building block for creating nucleoside analogs designed to inhibit cancer cell proliferation by interfering with DNA/RNA synthesis.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial-scale production of active pharmaceutical ingredients (APIs).
• Biochemical Research: Utilized as a substrate or inhibitor in enzymatic studies to understand nucleoside metabolism and related pathways.
• Custom Synthesis & Labeling: Acts as a starting point for the custom synthesis of isotopically labeled (e.g., 13C, 15N) versions for metabolic and pharmacokinetic studies.

Basic Information

Product Name	D-Ribofuranose, 1-C-(4-Aminopyrrolo[2,1-F][1,2,4]Triazin-7-Yl)-2,3,5-Tris-o-(Phenylmethyl)-
CAS No.	1355049-94-3
Molecular Formula	C29H30N6O4
Molecular Weight	526.59 g/mol
Synonyms	1-C-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,3,5-tris-O-(phenylmethyl)-D-ribofuranose; 4-Amino-7-((2R,3R,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,1-f][1,2,4]triazine; 7-((2R,3R,4R,5R)-3,4-Bis(benzyloxy)-5-((benzyloxy)methyl)tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine; Protected 4-Aminopyrrolotriazin-7-yl Ribofuranose Derivative; Benzyl-protected Nucleoside Analog Intermediate.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and high purity essential for research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development under cGMP guidelines for applications requiring regulatory filing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled and stored accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.