Description

[4-Fluoro-2-(Prop-2-Yn-1-Yloxy)Phenyl]Amine Hydrochloride is a high-purity, advanced pharmaceutical intermediate characterized by its unique molecular structure incorporating a fluoro-substituted aromatic ring and a propargyl ether linkage. This compound is of significant value in modern organic synthesis, particularly for the development of novel active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and inflammatory diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and pesticides, leveraging its fluorine moiety for enhanced biological activity and stability.
• Material Science Precursor: Serves as a monomer or functionalization agent in the creation of specialized polymers and advanced organic materials.
• Click Chemistry Applications: The alkyne (prop-2-yn-1-yloxy) group makes it an ideal substrate for copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions, a cornerstone of bioconjugation and chemical biology.
• Ligand Synthesis: Utilized for preparing novel ligands for catalysis and metal-organic frameworks (MOFs).
• Academic & Industrial R&D: A valuable reagent for methodological studies and exploratory chemistry in both university and corporate research laboratories.

Basic Information

Product Name	[4-Fluoro-2-(Prop-2-Yn-1-Yloxy)Phenyl]Amine Hydrochloride
CAS No.	1354950-12-1
Molecular Formula	C9H9ClFNO
Molecular Weight	201.62 g/mol
Synonyms	4-Fluoro-2-(prop-2-yn-1-yloxy)aniline hydrochloride; 2-Amino-5-fluorophenyl propargyl ether hydrochloride; 1-(2-Amino-5-fluorophenoxy)-2-propyne hydrochloride; 4-Fluoro-2-(2-propynyloxy)benzenamine hydrochloride; Propargyl 2-amino-5-fluorophenyl ether hydrochloride; 2-(Prop-2-yn-1-yloxy)-4-fluoroaniline hydrochloride; 4-Fluoro-2-(propagyloxy)aniline HCl
EINECS	Contact for details

Quality Control

Our [4-Fluoro-2-(Prop-2-Yn-1-Yloxy)Phenyl]Amine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for your most demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent decomposition. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.