Description

2-[4-Fluoro-3-(Methylsulfonyl)Phenyl]-1,3-Dioxolane is a high-value, fluorinated aromatic building block featuring a dioxolane protecting group and a methylsulfonyl electron-withdrawing substituent. This compound is critical for the synthesis of complex molecules, offering chemists a versatile handle for further functionalization in advanced organic reactions. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the production of advanced herbicides and fungicides, where the fluorine atom and sulfone group contribute to biological activity and metabolic stability.
• Material Science Research: Acts as a monomer or precursor for specialty polymers and advanced organic electronic materials due to its unique electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of fluorinated probes and tags for studying biological mechanisms and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global clients.
• Academic Research: Used in university and institutional laboratories for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	2-[4-Fluoro-3-(Methylsulfonyl)Phenyl]-1,3-Dioxolane
CAS No.	1354940-63-8
Molecular Formula	C10H11FO4S
Molecular Weight	246.26 g/mol
Synonyms	4-Fluoro-3-(methylsulfonyl)benzaldehyde ethylene acetal; 1,3-Dioxolane, 2-[4-fluoro-3-(methylsulfonyl)phenyl]-; [4-Fluoro-3-(methanesulfonyl)phenyl]-1,3-dioxolane; 2-(4-Fluoro-3-methanesulfonylphenyl)-1,3-dioxolane; 4-Fluoro-3-methanesulfonylbenzaldehyde ethylene acetal; 3-Methylsulfonyl-4-fluorobenzaldehyde ethylene acetal; FMSO-Benzaldehyde ethylene acetal (abbrev.)
EINECS	Contact for details

Quality Control

Our production of 2-[4-Fluoro-3-(Methylsulfonyl)Phenyl]-1,3-Dioxolane adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system supports compliance with cGMP and ISO standards for pharmaceutical and industrial applications, ensuring reliable supply and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. The container should be kept tightly sealed in a dry environment to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.