Description

(S)-n-Fmoc-γ-Iodo-Abu-Ome CAS NO 1354921-71-3 is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and medicinal chemistry research. This compound serves as a critical building block for introducing iodine-labeled side chains, enabling site-specific modifications, cross-coupling reactions, and the study of protein structure-function relationships. It is primarily utilized by pharmaceutical R&D teams, CROs, and academic laboratories focused on developing novel peptide-based therapeutics, diagnostics, and chemical probes.

Application

• Peptide Synthesis: Key intermediate for the solid-phase and solution-phase synthesis of complex, iodine-containing peptides.
• Medicinal Chemistry: Building block for creating peptide mimetics and novel chemical entities for drug discovery programs.
• Bioconjugation & Labeling: Facilitates the site-specific introduction of iodine atoms for radiolabeling (e.g., with I-125) or as a handle for further functionalization via cross-coupling reactions (e.g., Sonogashira, Suzuki).
• Chemical Biology Probes: Used to synthesize activity-based probes or photoaffinity labels for studying enzyme mechanisms and protein-protein interactions.
• Structure-Activity Relationship (SAR) Studies: Enables the systematic modification of peptide backbone structure to optimize potency, selectivity, and metabolic stability.
• Academic Research: Fundamental research tool in organic chemistry and biochemistry for developing new synthetic methodologies.

Basic Information

Product Name	(S)-n-Fmoc-γ-Iodo-Abu-Ome
CAS No.	1354921-71-3
Molecular Formula	C20H20INO4
Molecular Weight	465.28 g/mol
Synonyms	(S)-Methyl 2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-4-iodobutanoate; Fmoc-Abu(4-I)-OMe; Fmoc-4-iodo-L-homoalanine methyl ester; (S)-2-(((9H-Fluoren-9-ylmethoxy)carbonyl)amino)-4-iodobutanoic acid methyl ester; N-α-Fmoc-γ-iodo-L-homoalanine methyl ester; N-α-Fmoc-4-iodo-L-homoalanine methyl ester; Fmoc-L-Abu(4-I)-OMe; (S)-Methyl 4-iodo-2-(((9H-fluoren-9-ylmethoxy)carbonyl)amino)butanoate
EINECS	Contact for details

Quality Control

Our (S)-n-Fmoc-γ-Iodo-Abu-Ome is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles for the production of advanced pharmaceutical intermediates, ensuring traceability and documentation for regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) in a dry, cool place. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.