Description

L-Norleucine, 6-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- is a protected amino acid derivative, specifically a tert-butyloxycarbonyl (Boc) and fluorenylmethyloxycarbonyl (Fmoc) dual-protected norleucine analog. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors who require high-purity intermediates for the development of novel therapeutics, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of amino acids, particularly where the unique properties of norleucine are required.
• Pharmaceutical Research & Development: Used in the synthesis of peptide-based drug candidates, including metabolic inhibitors, hormone analogs, and antimicrobial peptides.
• Bioconjugation and Labeling: Serves as a modified amino acid residue for introducing specific functional groups or tags into peptide sequences.
• Structural Biology Studies: Incorporated into peptides to study protein folding, stability, and interactions, often as a non-natural, isosteric replacement.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse peptide libraries for high-throughput screening against biological targets.
• Agrochemical Research: Potential use in the development of bioactive peptide mimics for crop protection.

Basic Information

Item	Details
Product Name	L-Norleucine, 6-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-
CAS No.	1354752-71-8
Molecular Formula	C25H31NO5
Molecular Weight	425.52 g/mol
Synonyms	Fmoc-Nle(Boc)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N6-(tert-butoxycarbonyl)-L-norleucine; Nα-Fmoc-Nε-Boc-L-norleucine; Fmoc-L-norleucine(Boc)-OH; Boc-Nle(Fmoc)-OH; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoic acid
EINECS	Contact for details

Quality Control

Our L-Norleucine, 6-(1,1-Dimethylethoxy)-n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]- is manufactured under strict quality systems to ensure batch-to-batch consistency for sensitive research and production applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards required for GMP-guided synthesis and ISO-certified operations.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.