Description

Naloxegol Oxalate is a selective peripherally-acting mu-opioid receptor antagonist (PAMORA) used to treat opioid-induced constipation (OIC). This pharmaceutical active ingredient is critical for developing medications that counteract the gastrointestinal side effects of opioid pain therapy without affecting central analgesic effects. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of prescription drugs for chronic pain management.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of prescription medications for opioid-induced constipation (OIC).
• Drug Development & Research: Used in preclinical and clinical research for studying peripheral opioid receptor antagonism.
• Formulation Development: Serves as a key ingredient in the development of solid oral dosage forms, such as tablets and capsules.
• Reference Standard: Acts as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the commercial-scale production of finished drug products.
• Academic Research: Utilized in university and institutional studies focused on gastroenterology and pain management pharmacology.

Basic Information

Product Name	Naloxegol Oxalate
CAS No.	1354744-91-4
Molecular Formula	C34H53NO11 • C2H2O4
Molecular Weight	742.85 g/mol
Synonyms	Naloxegol Oxalate; Naloxegol hydrogen oxalate; (5α,6α)-17-Allyl-6-((20R)-20-(hydroxymethyl)-3,9,12,15-tetraoxa-18-azoniapentacosan-25-yloxy)-4,5-epoxymorphinan-3,14-diol hydrogen oxalate; NKTR-118 Oxalate; Moventig (brand name salt form); PAMORA; Opioid receptor antagonist NKTR-118
EINECS	Contact for details

Quality Control

Our Naloxegol Oxalate is manufactured under strict quality systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical development and manufacturing. We provide comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles, referencing relevant pharmacopeial guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.