Description

Fmoc-S-Carboxyethyl-L-Cysteine CAS NO 1354488-30-4 is a specialized, protected amino acid derivative designed for solid-phase peptide synthesis (SPPS). This compound is critical for the controlled introduction of cysteine residues with a side-chain carboxyl group, enabling advanced peptide engineering and bioconjugation. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers developing therapeutic peptides, protein mimetics, and diagnostic probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key building block for incorporating modified cysteine into peptide chains.
• Therapeutic Peptide Development: For creating peptides with enhanced stability, solubility, or specific bioactivity through side-chain functionalization.
• Bioconjugation and Linker Chemistry: The S-carboxyethyl side chain provides a handle for attaching fluorophores, drugs, or other molecules to peptides and proteins.
• Chemical Biology Research: Used in studying protein-protein interactions and developing enzyme inhibitors or receptor agonists/antagonists.
• Material Science: For synthesizing peptide-based polymers and biomaterials with tailored properties.

Basic Information

Product Name	Fmoc-S-Carboxyethyl-L-Cysteine
CAS No.	1354488-30-4
Molecular Formula	C₂₁H₂₁NO₆S
Molecular Weight	415.46 g/mol
Synonyms	Fmoc-Cys(COOH-CH₂-CH₂)-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-S-(2-carboxyethyl)-L-cysteine; Fmoc-S-(2-Carboxyethyl)-L-cysteine; Fmoc-Cys(CE)-OH; Fmoc-L-Cysteine(S-2-carboxyethyl); Fmoc-Cys(Carboxyethyl)-OH; (2R)-2-[(9H-Fluoren-9-ylmethoxy)carbonylamino]-3-[(2-carboxyethyl)sulfanyl]propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-S-Carboxyethyl-L-Cysteine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. Certificates of Analysis (COA) detailing all specifications are provided to guarantee compliance with research and pharmaceutical-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This material is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.