Description

1-(2-Chloro-5-Methyl-Pyrimidin-4-Yl)-[1,4]Diazepane is a high-purity, advanced pharmaceutical intermediate characterized by its unique diazepane-pyrimidine core structure. This compound is critical for the synthesis of complex bioactive molecules, offering a versatile building block for medicinal chemistry research and development. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in creating novel therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel small-molecule drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Development: Used in the construction of heterocyclic cores for potential kinase inhibitors, relevant in oncology research.
• Chemical Biology Probes: Employed in the development of tool compounds and probes for studying biological mechanisms and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for clients.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Product Name	1-(2-Chloro-5-Methyl-Pyrimidin-4-Yl)-[1,4]Diazepane
CAS No.	1354087-08-3
Molecular Formula	C10H15ClN4
Molecular Weight	226.71 g/mol
Synonyms	1-(2-Chloro-5-methylpyrimidin-4-yl)-1,4-diazepane; 4-(1,4-Diazepan-1-yl)-2-chloro-5-methylpyrimidine; 2-Chloro-5-methyl-4-(1,4-diazepan-1-yl)pyrimidine; 1,4-Diazepane, 1-(2-chloro-5-methyl-4-pyrimidinyl)-; 1354087-08-3; UNII-6J7J7W4J8I; 6J7J7W4J8I
EINECS	Contact for details

Quality Control

Our 1-(2-Chloro-5-Methyl-Pyrimidin-4-Yl)-[1,4]Diazepane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.