Description

6-((R)-Pyrrolidin-3-Yloxy)-Pyrimidin-4-Ylamine Hydrochloride is a high-purity chiral intermediate of significant importance in modern pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel, biologically active molecules, particularly in kinase inhibitor programs. It is primarily utilized by pharmaceutical companies and advanced research organizations engaged in the discovery of targeted therapeutics for oncology and other disease areas. The availability of this specific enantiomer is essential for ensuring the desired pharmacological profile and potency of the final drug candidate.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of small-molecule kinase inhibitors and other targeted therapies.
• Preclinical Drug Discovery: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology Probe Synthesis: Employed in the creation of tool compounds for studying specific biological pathways and target validation.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Academic Research: Utilized in university and institutional labs for investigating novel heterocyclic chemistry and its biological applications.

Basic Information

Product Name	6-((R)-Pyrrolidin-3-Yloxy)-Pyrimidin-4-Ylamine Hydrochloride
CAS No.	1354020-93-1
Molecular Formula	C9H15ClN4O
Molecular Weight	230.70 g/mol
Synonyms	(R)-6-(Pyrrolidin-3-yloxy)pyrimidin-4-amine hydrochloride; 4-Pyrimidinamine, 6-[(3R)-3-pyrrolidinyloxy]-, hydrochloride; 6-[(3R)-Pyrrolidin-3-yloxy]pyrimidin-4-amine HCl; (R)-6-(3-Pyrrolidinyloxy)-4-pyrimidinamine hydrochloride; 1354020-93-1; (R)-6-(Pyrrolidin-3-yloxy)pyrimidin-4-amine HCl salt
EINECS	Contact for details

Quality Control

Our 6-((R)-Pyrrolidin-3-Yloxy)-Pyrimidin-4-Ylamine Hydrochloride is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for research and development applications. We provide comprehensive analytical data including HPLC purity, chiral purity, and identity confirmation. A Certificate of Analysis (COA) detailing specifications and test results is supplied with each batch to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.