Description

(S)-3-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. Pharmaceutical R&D and process chemistry teams need this material for constructing complex molecular architectures, enabling the production of targeted, high-efficacy drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for kinase inhibitors and other targeted therapies.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) where the (S)-pyrrolidine scaffold is required.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and commercial-scale manufacturing processes for pharmaceutical compounds.
• Chemical Biology Research: Serves as a precursor for designing and synthesizing molecular probes to study biological pathways and enzyme functions.
• Asymmetric Synthesis: Utilized in catalytic and stoichiometric asymmetric transformations to introduce chirality into advanced intermediates.
• Custom Synthesis & Contract Manufacturing: A starting material for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for clients.

Basic Information

Product Name	(S)-3-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354020-92-0
Molecular Formula	C17H28N4O3S
Molecular Weight	368.49 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-ethoxy-2-methylsulfanylpyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (S)-tert-Butyl 3-((6-ethoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; 1-Boc-3-[(6-ethoxy-2-(methylthio)pyrimidin-4-yl)amino]-(S)-pyrrolidine; (S)-1-Boc-3-((6-ethoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine; CAS 1354020-92-0; BOC-Protected (S)-3-Amino Pyrrolidine Pyrimidine Derivative.
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP (current Good Manufacturing Practice) applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under a dry atmosphere or inert gas to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥97.0%
Chiral Purity (Chiral HPLC)	≥98.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.