Description

(S)-1-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is a high-purity chiral intermediate featuring a pyrimidine core substituted with ethoxy and methylthio groups, and a pyrrolidin-3-ol moiety. This compound is of significant value for its role in the synthesis of complex, biologically active molecules, particularly in pharmaceutical research and development. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing novel active ingredients and exploring new chemical entities. The precise stereochemistry and functional groups make it a critical building block for targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly for central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the development of advanced pesticides and herbicides where specific stereochemistry influences biological activity.
• Chemical Research: Serves as a versatile building block in academic and industrial laboratories for methodological studies in asymmetric synthesis and heterocyclic chemistry.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for complex molecules during late-stage development.
• Ligand & Catalyst Development: Potential precursor for creating novel chiral ligands or organocatalysts used in enantioselective transformations.

Basic Information

Product Name	(S)-1-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1354018-60-2
Molecular Formula	C11H17N3O2S
Molecular Weight	255.34 g/mol
Synonyms	(S)-1-(6-Ethoxy-2-(Methylthio)pyrimidin-4-yl)pyrrolidin-3-ol; (3S)-1-[6-Ethoxy-2-(methylsulfanyl)pyrimidin-4-yl]pyrrolidin-3-ol; 4-[(3S)-3-Hydroxypyrrolidin-1-yl]-6-ethoxy-2-methylsulfanylpyrimidine; (S)-3-Hydroxy-1-(6-ethoxy-2-(methylthio)pyrimidin-4-yl)pyrrolidine; Pyrrolidin-3-ol, 1-(6-ethoxy-2-(methylthio)-4-pyrimidinyl)-, (S)-; CAS 1354018-60-2
EINECS	Contact for details

Quality Control

Our (S)-1-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and away from moisture and direct light exposure. For long-term storage, consider using desiccants and storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.