Description

n-Cyclopropyl-N'-(S)-Pyrrolidin-3-Yl-Pyrimidine-4,6-Diamine Hydrochloride CAS NO 1354018-58-8 is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functionalized pyrimidine core. This compound is of significant value in modern medicinal chemistry for constructing complex molecules with targeted biological activity. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) for preclinical and clinical research.
• Kinase Inhibitor Development: Serves as a key structural component in the design and synthesis of potent and selective kinase inhibitors.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize drug candidate potency, selectivity, and pharmacokinetic properties.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying specific biological pathways and target validation.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	n-Cyclopropyl-N'-(S)-Pyrrolidin-3-Yl-Pyrimidine-4,6-Diamine Hydrochloride
CAS No.	1354018-58-8
Molecular Formula	C11H19ClN6
Molecular Weight	270.76 g/mol
Synonyms	4,6-Pyrimidinediamine, N-cyclopropyl-N'-[(3S)-3-pyrrolidinyl]-, monohydrochloride; (S)-N-Cyclopropyl-N'-(pyrrolidin-3-yl)pyrimidine-4,6-diamine hydrochloride; 1354018-58-8; UNII-9F8C2J7V8I; 9F8C2J7V8I; n-Cyclopropyl-N'-[(3S)-3-pyrrolidinyl]-4,6-pyrimidinediamine monohydrochloride; (S)-N-Cyclopropyl-N'-(3-pyrrolidinyl)-4,6-pyrimidinediamine hydrochloride
EINECS	Contact for details

Quality Control

Our n-Cyclopropyl-N'-(S)-Pyrrolidin-3-Yl-Pyrimidine-4,6-Diamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.