Description

(S)-3-(6-Ethoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, stereochemically defined building block for the development of novel active pharmaceutical ingredients (APIs). Pharmaceutical R&D and process chemistry teams need it for the efficient construction of complex molecules, particularly in therapeutic areas targeting central nervous system disorders and infectious diseases.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of novel drug candidates.
• API Development: Used in constructing the core scaffold of potential therapeutics, especially kinase inhibitors and other enzyme-targeting agents.
• Process Chemistry & Scale-Up: Serves as a critical starting material or advanced intermediate for optimizing synthetic routes from lab to pilot plant scale.
• Asymmetric Synthesis: Utilized in stereoselective reactions to introduce the (S)-configured pyrrolidine moiety into complex molecular architectures.
• Contract Manufacturing (CMO): Supplied to contract development and manufacturing organizations (CDMOs) for cGMP production of clinical trial materials.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies by providing a versatile, functionalized heterocyclic component for library synthesis.

Basic Information

Product Name	(S)-3-(6-Ethoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354018-05-5
Molecular Formula	C15H24N4O3
Molecular Weight	308.38 g/mol
Synonyms	(S)-tert-Butyl 3-((6-ethoxypyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-ethoxypyrimidin-4-yl)amino)pyrrolidine; (S)-3-[(6-Ethoxypyrimidin-4-yl)amino]-1-(tert-butoxycarbonyl)pyrrolidine; (S)-N-(6-Ethoxy-4-pyrimidinyl)-1-(tert-butoxycarbonyl)-3-pyrrolidinamine; 1-Boc-3-((6-ethoxypyrimidin-4-yl)amino)-(S)-pyrrolidine; BOC-(S)-3-((6-ethoxypyrimidin-4-yl)amino)pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Ethoxy-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chiral purity and chemical integrity, meeting the stringent requirements for pharmaceutical R&D and cGMP applications. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.