Description

(S)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it serves as a critical building block for the development of novel, targeted therapeutics, particularly in kinase inhibitor research. Pharmaceutical R&D and process chemistry teams need this intermediate for constructing complex active pharmaceutical ingredients (APIs) with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of advanced kinase inhibitors and other small molecule drugs.
• Preclinical & Clinical Research: Used in the discovery and development phases for new chemical entities (NCEs) targeting specific disease pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, optimization, and the manufacture of Active Pharmaceutical Ingredients (APIs) under cGMP conditions.
• Asymmetric Synthesis: Utilized in reactions requiring the introduction of a specific stereocenter, leveraging its defined (S)-configuration.
• Contract Manufacturing (CDMO): Supplied to contract development and manufacturing organizations for custom synthesis projects.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory filings.

Basic Information

Product Name	(S)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354015-15-8
Molecular Formula	C18H30N4O3
Molecular Weight	350.46 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-diethylamino-4-pyrimidinyl)oxy]-1-pyrrolidinecarboxylate; (S)-tert-Butyl 3-((6-(diethylamino)pyrimidin-4-yl)oxy)pyrrolidine-1-carboxylate; 1-Pyrrolidinecarboxylic acid, 3-[(6-(diethylamino)-4-pyrimidinyl)oxy]-, 1,1-dimethylethyl ester, (3S)-; BOC-(S)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine; (S)-3-(6-Diethylamino-4-Pyrimidinyloxy)-1-Boc-pyrrolidine; (S)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure it meets the stringent requirements for pharmaceutical R&D and manufacturing. Certificates of Analysis (COA) with detailed chromatographic data (HPLC, GC) are provided and can be tailored to support regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound may be hygroscopic (moisture-sensitive); therefore, containers should be kept tightly sealed and under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.