Description

(S)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. This compound is essential for research and process development chemists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable, high-quality intermediates for complex synthesis.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in medicinal chemistry research and development.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) where the (S)-pyrrolidine scaffold is required.
• Agrochemical Research: Serves as a precursor in the development of new pesticides and herbicides that utilize pyrimidine-based chemistry.
• Asymmetric Catalysis Studies: Employed as a substrate or ligand precursor in academic and industrial research focused on stereoselective synthesis.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and contract research organizations (CROs/CMOs) specializing in complex organic molecules.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying biological targets and pathways.

Basic Information

Product Name	(S)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354015-09-0
Molecular Formula	C15H23N3O4S
Molecular Weight	341.42 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-methoxy-2-methylsulfanylpyrimidin-4-yl)oxy]pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)oxy)pyrrolidine; (S)-3-(6-Methoxy-2-(methylthio)pyrimidin-4-yloxy)pyrrolidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)oxy)-(S)-pyrrolidine; (S)-1-(tert-Butoxycarbonyl)-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)oxy)pyrrolidine; BOC-(S)-3-(6-Methoxy-2-methylmercaptopyrimidin-4-yloxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our production of (S)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The product is manufactured and tested in facilities that follow cGMP (current Good Manufacturing Practice) guidelines where applicable. Comprehensive analytical testing, including HPLC, chiral HPLC, NMR, and MS, is performed to verify identity, purity, and enantiomeric excess. A detailed Certificate of Analysis (COA) is provided with each shipment, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to prevent oxidation and moisture uptake. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.