Description

(R)-3-(6-Ethoxy-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound matters because it provides a critical, enantiomerically pure building block for constructing complex active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring high stereochemical fidelity. Pharmaceutical R&D and manufacturing teams need this advanced intermediate for the development of novel drugs, where its defined stereochemistry is essential for ensuring target specificity and reducing off-target effects.

Application

This specialized chiral intermediate serves as a key synthon in several high-value pharmaceutical applications:

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel, enantiomerically pure Active Pharmaceutical Ingredients (APIs).
• Protease Inhibitor Development: Used in research and production of inhibitors targeting specific proteases, a common class for antiviral and anticancer therapies.
• Kinase Inhibitor Synthesis: Employed in constructing potent and selective kinase inhibitors, a major focus in oncology and inflammatory disease research.
• Asymmetric Synthesis: Serves as a chiral auxiliary or starting material in asymmetric catalytic processes to introduce stereocenters in complex molecules.
• Pre-clinical & Clinical Trial Material: Supplied as a GMP-grade intermediate for producing drug candidates for pre-clinical studies and clinical trial batches.
• Custom Synthesis & Contract Manufacturing: Provided to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chiral purity.

Basic Information

Product Name	(R)-3-(6-Ethoxy-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354014-71-3
Molecular Formula	C15H23N3O4
Molecular Weight	309.36 g/mol
Synonyms	1-Boc-(3R)-3-(6-ethoxy-4-pyrimidinyloxy)pyrrolidine; tert-Butyl (3R)-3-[(6-ethoxypyrimidin-4-yl)oxy]pyrrolidine-1-carboxylate; (R)-1-Boc-3-(6-ethoxy-pyrimidin-4-yloxy)-pyrrolidine; (R)-3-(6-Ethoxy-pyrimidin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester; BOC-(R)-3-(6-Ethoxy-4-pyrimidinyloxy)pyrrolidine; (R)-3-(6-Ethoxy-4-pyrimidinyloxy)-1-(tert-butoxycarbonyl)pyrrolidine; Pyrrolidine-1-carboxylic acid, 3-[(6-ethoxy-4-pyrimidinyl)oxy]-, 1,1-dimethylethyl ester, (3R)-
EINECS	Contact for details

Quality Control

Our production of (R)-3-(6-Ethoxy-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity, which is critical for pharmaceutical applications. We offer material produced under GMP (Good Manufacturing Practice) guidelines for advanced development phases. All batches are supported by comprehensive Certificates of Analysis (COA) detailing identity, purity (HPLC), chiral purity, and impurity profiles. Our quality system is designed to meet the rigorous standards of global regulatory submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light) and should be handled with materials compatible with strong acid/organic solvent. Keep the container tightly sealed to prevent moisture absorption and contamination. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.