Description

(S)-1-(6-Ethoxy-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is a high-purity chiral building block and pharmaceutical intermediate of significant commercial importance. Its defined stereochemistry and functionalized pyrimidine-pyrrolidine scaffold make it a valuable synthon for the research and development of novel active pharmaceutical ingredients (APIs). This compound is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers engaged in the synthesis of targeted therapeutics, particularly in areas requiring enantiomerically pure molecules.

Application

• Pharmaceutical Intermediate: A key chiral precursor in the synthesis of novel drug candidates, particularly for central nervous system (CNS) and antiviral targets.
• Asymmetric Synthesis Building Block: Utilized in medicinal chemistry for constructing complex molecules with defined stereocenters, leveraging its pyrrolidin-3-ol moiety.
• Chemical Reference Standard: Serves as a high-purity standard for analytical method development, quality control, and regulatory submissions.
• Agrochemical Research: Potential application as an intermediate in the development of new, selective agrochemicals due to its heterocyclic structure.
• Ligand and Catalyst Development: Can be employed in the design of chiral ligands or organocatalysts for asymmetric transformations.
• Academic and Contract Research: Used in university and CRO laboratories for exploratory research in synthetic organic and medicinal chemistry.

Basic Information

Product Name	(S)-1-(6-Ethoxy-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1354011-84-9
Molecular Formula	C11H17N3O2
Molecular Weight	223.27 g/mol
Synonyms	(3S)-1-(6-Ethoxy-4-pyrimidinyl)-3-pyrrolidinol; (S)-1-(6-Ethoxy-pyrimidin-4-yl)-pyrrolidin-3-ol; Pyrrolidin-3-ol, 1-(6-ethoxy-4-pyrimidinyl)-, (3S)-; (S)-3-Hydroxy-1-(6-ethoxypyrimidin-4-yl)pyrrolidine; 1354011-84-9; (S)-1-(6-Ethoxy-4-pyrimidinyl)pyrrolidin-3-ol; 4-Pyrimidinamine, 6-ethoxy-N-[(3S)-3-pyrrolidinyl]-
EINECS	Contact for details

Quality Control

Our (S)-1-(6-Ethoxy-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, chiral excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The container should be kept in a well-ventilated area. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.