Description

(R)-3-(6-Amino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate of significant commercial importance. Its value lies in its role as a key synthon for the development of novel, targeted therapeutics, particularly in oncology and antiviral research. This compound is essential for medicinal chemistry research, process development, and large-scale API manufacturing within the global pharmaceutical and biotechnology industries.

Application

• Pharmaceutical Intermediate: A critical chiral precursor in the synthesis of active pharmaceutical ingredients (APIs) for targeted cancer therapies.
• Medicinal Chemistry R&D: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Kinase Inhibitor Synthesis: Used in the construction of potent and selective kinase inhibitors, leveraging the pyrimidine and pyrrolidine pharmacophores.
• Process Chemistry: Employed in route scouting, scale-up, and the development of robust, GMP-compliant manufacturing processes for clinical and commercial supply.
• Bioconjugation & Probe Development: The tert-butyl ester protecting group and amino functionality allow for further derivatization to create diagnostic tools or targeted drug conjugates.

Basic Information

Product Name	(R)-3-(6-Amino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354011-40-7
Molecular Formula	C13H20N4O3
Molecular Weight	280.32 g/mol
Synonyms	tert-Butyl (3R)-3-[(6-aminopyrimidin-4-yl)oxy]pyrrolidine-1-carboxylate; (R)-1-Boc-3-(6-aminopyrimidin-4-yloxy)pyrrolidine; (R)-3-(6-Amino-4-pyrimidinyloxy)-1-(tert-butoxycarbonyl)pyrrolidine; 1-Boc-3R-(6-aminopyrimidin-4-yloxy)pyrrolidine; (R)-3-(6-Amino-pyrimidin-4-yloxy)-pyrrolidine-1-carboxylic acid tert-butyl ester; (R)-N-Boc-3-(6-aminopyrimidin-4-yloxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our production of (R)-3-(6-Amino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality management systems, ensuring batch-to-batch consistency and high purity suitable for advanced research and GMP manufacturing. All materials are characterized by advanced analytical techniques including HPLC, NMR, and MS. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are provided with every shipment to support your regulatory and development needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere to maintain stability and purity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.