Description

(R)-1-(6-Diethylamino-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is a high-purity chiral intermediate featuring a pyrimidine core substituted with a diethylamino group and a pyrrolidin-3-ol moiety. This compound is of significant value in pharmaceutical research and development, particularly for its role as a key building block in the synthesis of active pharmaceutical ingredients (APIs). It is primarily needed by R&D laboratories and manufacturers in the pharmaceutical and fine chemical industries working on novel therapeutics, including kinase inhibitors and other targeted small molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel Active Pharmaceutical Ingredients (APIs), especially in oncology and antiviral research.
• Kinase Inhibitor Development: Serves as a core structural component in the research and production of protein kinase inhibitors due to its pyrimidine scaffold.
• Asymmetric Synthesis: Used in chiral synthesis routes where the (R)-enantiomer is required for specific biological activity and reduced side effects.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Fine Chemical Production: Utilized in the multi-step synthesis of complex, high-value specialty chemicals for various industrial applications.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	(R)-1-(6-Diethylamino-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1354009-95-2
Molecular Formula	C12H20N4O
Molecular Weight	236.32 g/mol
Synonyms	(R)-1-[6-(Diethylamino)pyrimidin-4-yl]pyrrolidin-3-ol; (3R)-1-[6-(Diethylamino)pyrimidin-4-yl]pyrrolidin-3-ol; (R)-1-(6-Diethylaminopyrimidin-4-yl)pyrrolidin-3-ol; 1354009-95-2; (R)-1-(6-(Diethylamino)pyrimidin-4-yl)pyrrolidin-3-ol; Pyrrolidin-3-ol, 1-[6-(diethylamino)-4-pyrimidinyl]-, (3R)-; (R)-1-(6-Diethylamino-4-pyrimidinyl)-3-pyrrolidinol
EINECS	Contact for details

Quality Control

Our (R)-1-(6-Diethylamino-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with stringent industry standards for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request to support your regulatory and R&D needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and purity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.