Description

(S)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in the areas of kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs).
• Kinase Inhibitor Synthesis: Serves as a crucial scaffold for constructing potent and selective kinase inhibitors for oncology and inflammatory disease research.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to improve drug candidate potency and selectivity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds for client projects.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	(S)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354009-88-3
Molecular Formula	C15H24N4O3S
Molecular Weight	340.44 g/mol
Synonyms	(S)-tert-Butyl 3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine; (S)-3-((6-Methoxy-2-(methylthio)pyrimidin-4-yl)amino)-1-(tert-butoxycarbonyl)pyrrolidine; 1-Boc-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)-(S)-pyrrolidine; (S)-1-N-Boc-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine; (S)-3-Amino-1-Boc-pyrrolidine pyrimidine derivative
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.