Description

(R)-1-(6-Methoxy-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic value. Its core value lies in its defined stereochemistry and functionalized heterocyclic structure, which is critical for the development of enantiomerically pure active pharmaceutical ingredients (APIs). This compound is primarily needed by research institutions and pharmaceutical companies engaged in the discovery and process development of novel therapeutics, particularly in areas like kinase inhibitors and central nervous system (CNS) agents.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of advanced drug candidates and active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Utilized as a stereochemically defined scaffold for constructing complex molecules in medicinal chemistry and process R&D.
• Kinase Inhibitor Research: Serves as a core structural component in the development of potential kinase-targeted therapies.
• Chemical Biology Probes: Used in the design and synthesis of molecular probes for studying biological pathways and target engagement.
• Process Chemistry Development: Employed in route scouting and optimization for scalable GMP manufacturing of chiral drugs.
• Contract Research & Manufacturing (CRAM): Supplied to CROs and CDMOs supporting outsourced drug discovery and development programs.

Basic Information

Product Name	(R)-1-(6-Methoxy-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1354006-76-0
Molecular Formula	C9H13N3O2
Molecular Weight	195.22 g/mol
Synonyms	(3R)-1-(6-Methoxypyrimidin-4-yl)pyrrolidin-3-ol; (R)-3-Hydroxy-1-(6-methoxypyrimidin-4-yl)pyrrolidine; 1-(6-Methoxy-4-pyrimidinyl)-3-pyrrolidinol, (3R)-; 4-Pyrimidinamine, 6-methoxy-N-[(3R)-3-pyrrolidinyl]-; (R)-1-(6-Methoxy-4-pyrimidinyl)pyrrolidin-3-ol
EINECS	Contact for details

Quality Control

Our (R)-1-(6-Methoxy-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting standards for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (typically 15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.