Description

(R)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is specifically designed for the development of targeted therapeutics, offering a critical building block for medicinal chemists. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the discovery and production of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new drug candidates, particularly in kinase inhibitor programs.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a crucial building block in the multi-step synthesis of complex target molecules for preclinical and clinical studies.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize potency and selectivity of lead compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing scales.
• Asymmetric Synthesis: Leverages its defined (R)-stereochemistry to introduce chirality into more complex molecular architectures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.

Basic Information

Product Name	(R)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1354000-24-0
Molecular Formula	C17H28N4O3
Molecular Weight	336.43 g/mol
Synonyms	tert-Butyl (3R)-3-{[6-(diethylamino)pyrimidin-4-yl]oxy}pyrrolidine-1-carboxylate; (R)-1-Boc-3-((6-(diethylamino)pyrimidin-4-yl)oxy)pyrrolidine; BOC-(R)-3-(6-Diethylamino-pyrimidin-4-yloxy)-pyrrolidine; (R)-3-(6-Diethylaminopyrimidin-4-yloxy)-1-(tert-butoxycarbonyl)pyrrolidine; 1-Boc-3-((6-(diethylamino)pyrimidin-4-yl)oxy)-(R)-pyrrolidine; (R)-N-Boc-3-(6-(diethylamino)pyrimidin-4-yloxy)pyrrolidine
EINECS	Contact for details

Quality Control

Our (R)-3-(6-Diethylamino-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. The product undergoes rigorous analytical testing, including chiral HPLC, to ensure high chemical and enantiomeric purity suitable for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data are provided with each batch to support regulatory filings and ensure traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.