Description

(R)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate of significant commercial and research interest. This chiral compound serves as a critical building block in the synthesis of novel, targeted therapeutic agents, particularly within kinase inhibitor development. It is essential for medicinal chemistry research, process development, and cGMP manufacturing in the global pharmaceutical and biotechnology sectors.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and commercial synthesis of potent kinase inhibitors and other small molecule APIs.
• Medicinal Chemistry R&D: Used for structure-activity relationship (SAR) studies, lead optimization, and the discovery of new drug candidates targeting specific disease pathways.
• Process Chemistry & Scale-Up: Employed in route scouting, process optimization, and the development of robust, scalable synthetic pathways for active pharmaceutical ingredients (APIs).
• cGMP Manufacturing: Supplied under strict quality protocols for use in the production of clinical trial materials and commercial drug substances.
• Biochemical Research: Utilized as a tool compound or precursor in biochemical assays to study enzyme function and cellular signaling mechanisms.

Basic Information

Product Name	(R)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353997-36-0
Molecular Formula	C16H26N6O2
Molecular Weight	334.42 g/mol
Synonyms	(R)-tert-Butyl 3-((6-(cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; (R)-1-Boc-3-((6-(cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine; (R)-3-[(6-Cyclopropylamino-4-pyrimidinyl)amino]-1-pyrrolidinecarboxylic Acid 1,1-Dimethylethyl Ester; (R)-3-((6-(Cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester; Boc-(R)-3-((6-(Cyclopropylamino)pyrimidin-4-yl)amino)pyrrolidine; 1353997-36-0; (R)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
EINECS	Contact for details

Quality Control

Our (R)-3-(6-Cyclopropylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure compliance with stringent pharmaceutical-grade specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment. We support development and commercial projects with cGMP-compliant documentation and stability data as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccant and an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.