Description

(R)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is critical for the synthesis of complex, biologically active molecules, particularly in the development of targeted therapeutics. It is primarily needed by pharmaceutical R&D departments and fine chemical manufacturers engaged in the production of novel drug candidates, especially within oncology and antiviral research.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of active pharmaceutical ingredients (APIs) for clinical development.
• Protease Inhibitor Research: Serves as a core structural component in the design and synthesis of novel protease inhibitors.
• Kinase Inhibitor Development: Used in the construction of heterocyclic scaffolds for potential kinase-targeted therapies in oncology.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective chemical reactions to introduce the (R)-pyrrolidine moiety.
• Chemical Biology: Employed in the synthesis of molecular probes and tool compounds for studying enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities for process optimization and GMP manufacturing campaigns.

Basic Information

Product Name	(R)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353996-89-0
Molecular Formula	C15H24N4O3S
Molecular Weight	340.44 g/mol
Synonyms	tert-Butyl (3R)-3-[(6-methoxy-2-methylsulfanylpyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (R)-1-Boc-3-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine; (R)-3-((6-Methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester; (R)-1-N-Boc-3-amino-4-((6-methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine; BOC-(R)-3-((6-Methoxy-2-(methylthio)pyrimidin-4-yl)amino)pyrrolidine; (R)-Boc-3-APy(Ms)
EINECS	Contact for details

Quality Control

Our (R)-3-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC to ensure enantiomeric purity and identity confirmation by NMR and mass spectrometry. Certificates of Analysis (COA) with full traceability are provided, and production can be aligned with cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.