Description

(S)-3-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. This compound is valued for its role as a key building block in the development of active pharmaceutical ingredients (APIs), particularly those targeting complex biological pathways. It is primarily sought after by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, where precise stereochemistry and reliable quality are paramount.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the multi-step synthesis of complex drug candidates, especially in medicinal chemistry research.
• API Development: Used as a building block for constructing the core scaffold of potential Active Pharmaceutical Ingredients (APIs) in discovery and process development.
• Asymmetric Synthesis: Leverages its defined (S)-stereochemistry for the synthesis of enantiomerically pure compounds, crucial for drug efficacy and safety profiles.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and creating libraries of novel chemical entities.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing route of advanced pharmaceutical compounds.

Basic Information

Product Name	(S)-3-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353996-78-7
Molecular Formula	C16H25N3O4S
Molecular Weight	355.45 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-ethoxy-2-methylsulfanylpyrimidin-4-yl)oxy]pyrrolidine-1-carboxylate; (S)-1-Boc-3-((6-ethoxy-2-(methylthio)pyrimidin-4-yl)oxy)pyrrolidine; (S)-3-(6-Ethoxy-2-(methylthio)pyrimidin-4-yloxy)pyrrolidine-1-carboxylic acid tert-butyl ester; 1-Boc-3-((6-ethoxy-2-(methylthio)pyrimidin-4-yl)oxy)-(S)-pyrrolidine; BOC-(S)-3-(6-Ethoxy-2-methylsulfanyl-pyrimidin-4-yloxy)-pyrrolidine
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Ethoxy-2-Methylsulfanyl-Pyrimidin-4-Yloxy)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.