Description

(S)-3-(6-Diethylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate critical for modern drug discovery and development. This compound serves as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for targeted therapies. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical sectors, where precise molecular architecture is required.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of novel drug candidates, especially kinase inhibitors and other targeted small-molecule therapeutics.
• API Development: Used as a key building block in the research, development, and scale-up production of Active Pharmaceutical Ingredients (APIs) requiring a specific (S)-configured pyrrolidine scaffold.
• Medicinal Chemistry Research: Enables structure-activity relationship (SAR) studies and lead optimization in drug discovery programs focused on pyrimidine-based compounds.
• Process Chemistry & Scale-Up: Serves as a validated intermediate for process development and commercial-scale GMP manufacturing of final drug substances.
• Bioconjugation & Probe Synthesis: Can be utilized in the development of chemical probes, diagnostic agents, or antibody-drug conjugates (ADCs) due to its functionalized amine group.
• Contract Manufacturing (CMO/CDMO): Supplied to contract research and manufacturing organizations for use in client-specific synthesis projects.

Basic Information

Product Name	(S)-3-(6-Diethylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1353995-37-5
Molecular Formula	C18H31N5O2
Molecular Weight	349.48 g/mol
Synonyms	tert-Butyl (3S)-3-[(6-diethylaminopyrimidin-4-yl)amino]pyrrolidine-1-carboxylate; (S)-tert-Butyl 3-((6-(diethylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylate; 1-Boc-3-[(6-diethylamino-4-pyrimidinyl)amino]-(S)-pyrrolidine; (S)-1-Boc-3-((6-(diethylamino)pyrimidin-4-yl)amino)pyrrolidine; (S)-3-((6-(Diethylamino)pyrimidin-4-yl)amino)pyrrolidine-1-carboxylic acid tert-butyl ester; BOC-protected (S)-3-amino pyrrolidine pyrimidine derivative; (S)-3-(6-Diethylamino-pyrimidin-4-ylamino)-pyrrolidine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our (S)-3-(6-Diethylamino-Pyrimidin-4-Ylamino)-Pyrrolidine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.