Description

(R)-1-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol is a high-purity chiral intermediate featuring a substituted pyrimidine core linked to a pyrrolidine ring. This compound is of significant value for its role as a key building block in the synthesis of complex, biologically active molecules. It is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new therapeutic agents, particularly in areas requiring stereochemical control.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis: Used in the construction of complex molecules where the (R)-configured pyrrolidin-3-ol moiety is essential for biological activity.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry & Scale-up: Employed in the development of efficient, scalable synthetic routes for candidate drugs during clinical and commercial manufacturing stages.
• Chemical Biology Probes: Can be utilized in the design and synthesis of molecular probes for studying enzyme mechanisms or biological pathways.

Basic Information

Product Name	(R)-1-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol
CAS No.	1353995-31-9
Molecular Formula	C10H15N3O2S
Molecular Weight	241.31 g/mol
Synonyms	(3R)-1-(6-Methoxy-2-(methylthio)-4-pyrimidinyl)-3-pyrrolidinol; (R)-3-Hydroxy-1-(6-methoxy-2-(methylthio)pyrimidin-4-yl)pyrrolidine; 1-(6-Methoxy-2-(methylthio)-4-pyrimidinyl)-(3R)-3-pyrrolidinol; (R)-1-(6-Methoxy-2-(methylsulfanyl)pyrimidin-4-yl)pyrrolidin-3-ol; Pyrrolidin-3-ol, 1-(6-methoxy-2-(methylthio)-4-pyrimidinyl)-, (3R)-; (R)-enantiomer of 1-(6-Methoxy-2-methylsulfanyl-pyrimidin-4-yl)-pyrrolidin-3-ol
EINECS	Contact for details

Quality Control

Our production of (R)-1-(6-Methoxy-2-Methylsulfanyl-Pyrimidin-4-Yl)-Pyrrolidin-3-Ol adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. All materials are characterized by advanced analytical techniques including HPLC, GC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with each shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for prolonged operations to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.